Not all placental allograftsare created equal

The differences in preservation matter

Placental allografts have been used for their regenerative properties for over a century—the fetal membrane was first used for the transplantation of skin in 1910.1 As innovations were made over time, the preservation methods can vary with each commercially available product.

Some manufacturers remove part of the placental membrane—including the amnion, chorion, epithelium, or spongy layer—which also removes important components that can result in a decrease of growth factors or proteins.2

The more a placental allograft is manipulated, including the removal of layers, the more limited the growth factor content. Preserving more layers results in higher levels of growth factors and cytokines.1-6

Properties of human amnion and chorion6

PropertyAmnionChorion
Extracellular matrix (ECM): structural matrixCollagens I, III, IV, V, VI, elastinCollagens I, III, IV, V, VI, tropoelastin
ECM: glycoproteinsFibronectin, laminins, nidogenFibronectin, laminins, nidogen
ECM: proteoglycansChondroitin, dermatan sulfate, hyaluronan, decorin, biglycanChondroitin, dermatan sulfate, hyaluronan, decorin, biglycan, versican, perlican
Selected growth factorsaEGF, HGF, TGF-β1, TGF-β3, bFGF, KGF, NGF, VEGF, PDGF, PIGF, TGF-αHGF, TGF-β1, TGF-α, bFGF, VEGF, PDGF, PIGF
MucinInterferon α
DefensinsDefensins
TIMPS, CTGF, IL-1RATIMP-1
Groα, sICAM, IL-6, IL-8, MCP-1, MIF, serpin E1, SDF-1a, IL-10, IL-4, G-CSFIL-6, IL-8, IL-4, SDF-1a, IL-10, GCSF
aMost amniotic growth factors are also present in chorion. Table reproduced from Brantley, et al. Adv Wound Care. 2015;4(9):545-559.6

By retaining all native layers, including the amnion, chorion, and spongy layer, NuShield® is the most complete dehydrated placental allograft wound covering.7-10

Optimizing the environment for healing

Discover the native layers of NuShield, or contact an Organogenesis Tissue Regeneration Specialist to see how NuShield can help create a favorable environment for healing across different wound types.

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REFERENCES:

  1. Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
  2. Koob TJ, et al. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
  3. McQuilling JP, et al. Wounds. 2017;29(6):E38-E42.
  4. McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
  5. Abshier S. Podiatry Today. 2015;28(11):20-26.
  6. Brantley JN, et al. Adv Wound Care. 2015;4(9):545-559.
  7. Data on file. Description of BioLoc Process.
  8. McQuilling JP, et al. Int Wound J. 2019;16(3):827-840.
  9. McQuilling JP, et al. Wound Repair Regen. 2019;27(6):609-621.
  10. Data on file. DR-0004. Organogenesis Inc.