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Not all placental allograftsare created equal

The differences in preservation matter

Placental allografts have been used for over a century—the fetal membrane was first used for the transplantation of skin in 1910.1 As innovations were made over time, the preservation methods can vary with each commercially available product.

Some manufacturers remove part of the placental membrane—including the amnion, chorion, epithelium, or spongy layer—which also removes important components and alters the native tissue composition.2

The more a placental allograft is processed, including the removal of layers, the more limited the ECM protein and growth factor content. Preserving more layers retains the native tissue composition including structural proteins, growth factors, and cytokines.1-6

Properties of human amnion and chorion6

PropertyAmnionChorion
Extracellular matrix (ECM): structural matrixCollagens I, III, IV, V, VI, elastinCollagens I, III, IV, V, VI, tropoelastin
ECM: glycoproteinsFibronectin, laminins, nidogenFibronectin, laminins, nidogen
ECM: proteoglycansChondroitin, dermatan sulfate, hyaluronan, decorin, biglycanChondroitin, dermatan sulfate, hyaluronan, decorin, biglycan, versican, perlican
Selected growth factorsaEGF, HGF, TGF-β1, TGF-β3, bFGF, KGF, NGF, VEGF, PDGF, PIGF, TGF-αHGF, TGF-β1, TGF-α, bFGF, VEGF, PDGF, PIGF
MucinInterferon α
DefensinsDefensins
TIMPS, CTGF, IL-1RATIMP-1
Groα, sICAM, IL-6, IL-8, MCP-1, MIF, serpin E1, SDF-1a, IL-10, IL-4, G-CSFIL-6, IL-8, IL-4, SDF-1a, IL-10, GCSF
aMost amniotic growth factors are also present in chorion. Table reproduced from Brantley, et al. Adv Wound Care. 2015;4(9):545-559.6

As a wound covering, NuShield supports the healing environment

Discover the native layers of NuShield, or contact an Organogenesis Tissue Regeneration Specialist to see how NuShield can help support a favorable environment for healing across different wound types.

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NuShield is intended to be used as a wound covering and barrier.
Please refer to the NuShield instructions for use for usage and safety information.

REFERENCES:

  1. Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
  2. Koob TJ, et al. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
  3. McQuilling JP, et al. Wounds. 2017;29(6):E38-E42.
  4. McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
  5. Abshier S. Podiatry Today. 2015;28(11):20-26.
  6. Brantley JN, et al. Adv Wound Care. 2015;4(9):545-559.