Not all placental allograftsare created equal
The differences in preservation matter
Placental allografts have been used for their regenerative properties for over a century—the fetal membrane was first used for the transplantation of skin in 1910.1 As innovations were made over time, the preservation methods can vary with each commercially available product.
Some manufacturers remove part of the placental membrane—including the amnion, chorion, epithelium, or spongy layer—which also removes important components that can result in a decrease of growth factors or proteins.2
The more a placental allograft is manipulated, including the removal of layers, the more limited the growth factor content. Preserving more layers results in higher levels of growth factors and cytokines.1-6
Properties of human amnion and chorion6
|Extracellular matrix (ECM): structural matrix||Collagens I, III, IV, V, VI, elastin||Collagens I, III, IV, V, VI, tropoelastin|
|ECM: glycoproteins||Fibronectin, laminins, nidogen||Fibronectin, laminins, nidogen|
|ECM: proteoglycans||Chondroitin, dermatan sulfate, hyaluronan, decorin, biglycan||Chondroitin, dermatan sulfate, hyaluronan, decorin, biglycan, versican, perlican|
|Selected growth factorsa||EGF, HGF, TGF-β1, TGF-β3, bFGF, KGF, NGF, VEGF, PDGF, PIGF, TGF-α||HGF, TGF-β1, TGF-α, bFGF, VEGF, PDGF, PIGF|
|TIMPS, CTGF, IL-1RA||TIMP-1|
|Groα, sICAM, IL-6, IL-8, MCP-1, MIF, serpin E1, SDF-1a, IL-10, IL-4, G-CSF||IL-6, IL-8, IL-4, SDF-1a, IL-10, GCSF|
By retaining all native layers, including the amnion, chorion, and spongy layer, NuShield® is the most complete dehydrated placental allograft wound covering.7-10
- Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
- Koob TJ, et al. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
- McQuilling JP, et al. Wounds. 2017;29(6):E38-E42.
- McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
- Abshier S. Podiatry Today. 2015;28(11):20-26.
- Brantley JN, et al. Adv Wound Care. 2015;4(9):545-559.
- Data on file. Description of BioLoc Process.
- McQuilling JP, et al. Int Wound J. 2019;16(3):827-840.
- McQuilling JP, et al. Wound Repair Regen. 2019;27(6):609-621.
- Data on file. DR-0004. Organogenesis Inc.