More growth factors, cytokines, hyaluronic acid, and thickness

Compared to another commercially available dehydrated human amnion/chorion membrane (dHACM)1

NuShield® contains 42% higher concentrations of growth factors and cytokines1

Note: * indicates significance where P<0.05; indicates significance where P<0.01.

A broad evaluation of proteins found that NuShield, compared to another commercially available dHACM, retained statistically significant higher concentrations of many growth factors and cytokines1

NuShield contains, on average, over 6x more hyaluronic acid1

HA holds vast amounts of moisture, serves as filling material for ECM, and acts as an adhesive substrate for cellular migration.2

In this evaluation, HA levels were significantly higher in NuShield than in another commercially available dHACM, with an average of 3.25 μg/cm2 HA in NuShield compared to 0.52 μg/cm2 HA in the other commercially available dHACM.1

NuShield provides more thickness due to the retention of the spongy layer

An evaluation of graft structure and growth factor distribution found that the preservation method used by another commercially available dHACM removes most of the spongy layer, making it, on average, thinner than NuShield.1

NuShield

Another commercially available dHACM

Histological assessment with immunohistochemistry for hematoxylin and eosin, hyaluronic acid, and hepatocyte growth factor. Each stain shows a representative image taken with a 20x objective for each donor.1

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REFERENCES:

  1. Data on file. DR-0004-2018-07-03. Organogenesis Inc.
  2. Litwiniuk M, et al. Wounds. 2016;28(3):78-88.