The Nu Solution

NuShield® preserves key components to help create an environment for healing

The amnion and chorion are multilayered tissues, with each layer performing a specialized function that contributes unique characteristics to the tissue as a whole.1 LayerLoc™ is a novel preservation method that not only retains the native amnion and chorion, but also leaves the spongy layer intact, locking in regulatory proteins.2,3

The unique preservation method retains all native layers

In vitro, preserving the amnion layer was demonstrated to retain an abundant source of growth factors/cytokines and ECM.3

Including the chorion layer results in a thicker graft, which may improve handling characteristics4

The spongy layer supports healing

The spongy layer is a rich source of specific growth factors and proteins beneficial to the wound healing process.3-5

In an in vitro study, the spongy layer in NuShield contained the following substances, growth factors, and matrix proteins.3,4:

  • Hyaluronic acid (HA)
  • Transforming growth factor beta 1 (TGF-β1)
  • Hepatocyte growth factor (HGF)
  • Interleukin-1 receptor antagonist (IL-1ra)
The clinical activity of these factors has not been demonstrated in NuShield.

Accessible and supported

View product information to see the wide range of shapes and sizes available, or contact an Organogenesis Tissue Regeneration Specialist to see how NuShield can be used for a variety of wounds.

Contact us


  1. Abshier S. Podiatry Today. 2015;28(11):20-26.
  2. Data on file. Description of BioLoc Process.
  3. McQuilling JP, et al. Int Wound J. 2019;16(3):827-840.
  4. Data on file. DR-0004. Organogenesis Inc.
  5. McQuilling JP, et al. Wounds. 2017;29(6):E38-E42.