The Nu Solution

NuShield is a protective barrier and ECM scaffold that retains key components

The amnion and chorion are multilayered tissues, with each layer contributing unique characteristics to the tissue as a whole.¹ LayerLoc™ is a novel preservation method that not only retains the native amnion and chorion, but also leaves the spongy layer intact, locking in regulatory proteins.^2,3

The unique preservation method retains all native layers

In vitro, preserving the amnion layer was demonstrated to retain an abundant source of growth factors/cytokines and ECM.³

Including the chorion layer results in a thicker graft, which may improve handling characteristics⁴

Composition of the spongy layer in NuShield

In an analytical study, the spongy layer in NuShield contained the following substances, growth factors, and matrix proteins^3,4:

• Hyaluronic acid (HA)
• Transforming growth factor beta 1 (TGF-β1)
• Hepatocyte growth factor (HGF)
• Interleukin-1 receptor antagonist (IL-1Ra)

The clinical activity of these factors has not been demonstrated in NuShield.