The Nu Difference

Complete layers set NuShield® apart

NuShield is a shelf-stable, dehydrated placental allograft wound covering that undergoes a unique preservation method.

  • NuShield retains all layers of the placental membrane, including the spongy layer, for a more complete growth factor release1,2
  • In vitro, growth factor proteins in NuShield continue to be released over a 7-day period2

The most complete dehydrated placental allograft wound covering

NuShield is an effective choice as a natural dehydrated placental allograft wound covering for a variety of partial- and full-thickness acute and chronic wounds, with a unique preservation method that retains1,3:

Numerous growth factors and cytokines with angiogenic, regenerative, and anti-inflammatory properties.2,4

All the native amnion and chorion layers with the spongy layer intact, unlike many placental allografts on the market2

Proven growth factor release

In vitro studies have shown that NuShield:

  • Contains 640 proteins, including growth factors, cytokines, and chemokines4
  • Releases growth factors and cytokines over a 7-day period to help create a favorable environment for healing2
  • Increases fibroblast and keratinocyte proliferation and migration2

In vitro, the proprietary preservation method for NuShield retains numerous growth factors and cytokines. These growth factors and cytokines are known to have angiogenic, regenerative, and anti-inflammatory properties.*5

Anti-inflammatory cytokines
TIMP-1
TIMP-2
TIMP-4
IL-1F5
IL-1Ra
Angiogenic growth factors
aFGF
ANG
ANGPTL4
bFGF
EG-VEGF
PIGF
TSP-1
VEGF
Regenerative growth factors
Galectin-7
HGF
IGFBP-1
IGFBP-5
IGF-1
IGF-2
PDGF
SDF-1
TGF-β1
*This is not an exhaustive list.

In vitro, NuShield continues to release growth factors over a 7-day period

An in vitro study demonstrated NuShield releases 32% of growth factors at 12 hours and 94% by 7 days.2

Total growth factor and cytokine release

Helping create an environment for healing

See the preservation method that sets NuShield apart, or contact an Organogenesis Tissue Regeneration Specialist to see how NuShield can help your patients.

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REFERENCES:

  1. Data on file. Description of BioLoc Process.
  2. McQuilling JP, et al. Int Wound J. 2019;16(3):827-840.
  3. NuShield Allograft Tissue Information and Instructions for Use. Canton, MA: Organogenesis Inc; 2019.
  4. McQuilling JP, et al. Wound Repair Regen. 2019;27(6):609-621.
  5. McQuilling JP, et al. Wounds. 2017;29(6):E38-E42.