NEW CASE STUDIES: SEE HOW NUSHIELD® HELPED TO SUPPORT HEALING

Not all placental allograftsare created equal

The differences in preservation matter

Placental allografts have been used for over a century—the fetal membrane was first used for the transplantation of skin in 1910.1 As innovations were made over time, the preservation methods can vary with each commercially available product.

Some manufacturers remove part of the placental membrane—including the amnion, chorion, epithelium, or spongy layer—which also removes important components and alters the native tissue composition.2

The more a placental allograft is processed, including the removal of layers, the more limited the ECM protein and growth factor content. Preserving more layers retains the native tissue composition including structural proteins, growth factors, and cytokines. The ECM is an important scaffold that has been shown to support cellular attachment.1-6

Properties of human amnion and chorion6

Property Amnion Chorion
Extracellular matrix (ECM): structural matrix Collagens I, III, IV, V, VI, elastin Collagens I, III, IV, V, VI, tropoelastin
ECM: glycoproteins Fibronectin, laminins, nidogen Fibronectin, laminins, nidogen
ECM: proteoglycans Chondroitin, dermatan sulfate, hyaluronan, decorin, biglycan Chondroitin, dermatan sulfate, hyaluronan, decorin, biglycan, versican, perlican
Selected growth factorsa EGF, HGF, TGF-β1, TGF-β3, bFGF, KGF, NGF, VEGF, PDGF, PIGF, TGF-α HGF, TGF-β1, TGF-α, bFGF, VEGF, PDGF, PIGF
Mucin Interferon α
Defensins Defensins
TIMPS, CTGF, IL-1RA TIMP-1
Groα, sICAM, IL-6, IL-8, MCP-1, MIF, serpin E1, SDF-1a, IL-10, IL-4, G-CSF IL-6, IL-8, IL-4, SDF-1a, IL-10, GCSF
aMost amniotic growth factors are also present in chorion. Table reproduced from Brantley, et al. Adv Wound Care. 2015;4(9):545-559.6

NuShield supports the healing environment

Discover the native layers of NuShield, or contact an Organogenesis Tissue Regeneration Specialist to see how NuShield can help support a favorable environment for healing across different wound types.

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Please refer to the NuShield instructions for use for usage and safety information.

REFERENCES:

  1. Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
  2. Koob TJ, et al. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
  3. McQuilling JP, et al. Wounds. 2017;29(6):E38-E42.
  4. McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
  5. Abshier S. Podiatry Today. 2015;28(11):20-26.
  6. Brantley JN, et al. Adv Wound Care. 2015;4(9):545-559.